Current Opinion in Chemical Biology 2021, 63, 123-131.
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Chemogenetic and optogenetic control of post-translational modifications through genetic code expansion. Journal of Biological Chemistry 2021, 297 Human CEACAM1-LF regulates lipid storage in HepG2 cells via fatty acid transporter CD36. Jennifer Chean, Charng-Jui Chen, Gabriel Gugiu, Patty Wong, Seung Cha, Harry Li, Tung Nguyen, Supriyo Bhatticharya, John E.PAT-PseAAC: Prediction of acetyl threonine in protein sites with statistical moments and chou’s 5 step rule. Exploring kinase family inhibitors and their moiety preferences using deep SHapley additive exPlanations. You-Wei Fan, Wan-Hsin Liu, Yun-Ti Chen, Yen-Chao Hsu, Nikhil Pathak, Yu-Wei Huang, Jinn-Moon Yang.Skeletal muscle-specific overexpression of miR-486 limits mammary tumor-induced skeletal muscle functional limitations. Current Chemical Biology Approaches to Interrogate Protein Methyltransferases. Journal of the American Chemical Society 2012, 134 Azalysine Analogues as Probes for Protein Lysine Deacetylation and Demethylation. Jelinek, Ananya Majumdar, Yan Sun, Beverley M. Substrate Specificity, Processivity, and Kinetic Mechanism of Protein Arginine Methyltransferase 5. Identification of Enriched PTM Crosstalk Motifs from Large-Scale Experimental Data Sets. Protein Arginine Methyltransferase 5 Catalyzes Substrate Dimethylation in a Distributive Fashion. Discovery of Arginine Methylation, Phosphorylation, and Their Co-occurrence in Condensate-Associated Proteins in Saccharomyces cerevisiae. Integrated Phosphoproteomics for Identifying Substrates of Human Protein Kinase A (PRKACA) and Its Oncogenic Mutant DNAJB1–PRKACA. Adak Karamafrooz, Jack Brennan, David D.This article is cited by 65 publications. In addition, we predict likely examples of crosstalk between protein arginine methyltransferase 1 (PRMT1) and Akt and discuss the future implications of these findings. In this review, we discuss several recent examples of non-histone kinase consensus sequence crosstalk, as well as provide the biophysical basis for these observations. Therefore, we hypothesize that non-histone crosstalk between serine/threonine phosphorylation and arginine/lysine modifications is a global mechanism for the modulation of cellular signaling. Interestingly, many kinase consensus sequences contain critical arginine/lysine residues surrounding the substrate serine/threonine residue. Recently, however, non-histone crosstalk has been observed between serine/threonine phosphorylation and the modification of arginine and lysine residues within kinase consensus sequences. These examples demonstrate the critical roles that crosstalk plays in regulating cell signaling pathways. The best characterized examples of crosstalk between two or more different post-translational modifications (PTMs) occur with respect to histones.